On the other hand, high KANK1 mRNA expression showed a significant positive association with E-cadherin gene (CDH1), and these findings suggest that high KANK1 expression is involved in reducing tumour cell migration and influencing the LVI process through reducing the RhoA/ROCK pathway, which has a well-known role in controlling cancer cell migration [7]. This evidence concerns the gene KANK1 and neoplasm.