CD8A and liver cancer: GZK has been previously reported to be over-expressed in a particular subset of CD8+T cells isolated by single-cell sequencing of liver cancer-infiltrating T cells where different clusters of infiltrating CD8+T cells were identified according to transcriptional features and notably a GZK-expressing cluster sharing some exhausted transcriptional characteristics with uncommon activation markers but different from the typical exhausted CD8+ cluster [25].