In HT29 cells, STAT-Y701 is phosphorylated as a response to exogenous IFNs such as IFNs I, II, and III; furthermore, infected HT29 cell with simian RRV RV strain or Porcine SB1-A showed a decline in the level of IFN-γ1 receptor gene expression occurring 6-8 h post infection with these two viruses. This evidence concerns the gene SOAT1 and infection.