NES and human granulocytic anaplasmosis: Multivariate Cox's regression further illustrated that higher Nestin expression independently predicted poor OS in HGA patients (P = .023, HR = 1.584) and immunotherapy independently predicted longer OS (P = .042, HR = 0.214), while higher CD133 expression (P = .625, HR = 1.131), age (>40 vs ≤40 years) (P = .162, HR = 1.533), gender (P = .110, HR = 1.846), radiotherapy (P = .306, HR = 0.637), and chemotherapy (P = .376, HR = 1.436) were not independent predictive factors for OS in HGA patients (Table 5).