This impaired barrier provides a favourable environment for S. aureus colonization.89, 90, 91, 92 The deposition of stratum corneum (SC) fibronectin, to which S. aureus adheres, is increased in AD.26, 93, 94Staphylococcus aureus clumping factor B binds to loricrin and cytokeratin 10 and promotes adhesion of S. aureus to the stratum corneum in AD.95 Antimicrobial peptides (AMPs) such as β‐defensins and cathelicidins are also reduced in AD lesions.96 Here, FN1 is linked to Alzheimer disease.