Among the components of MACCEs, serum sclerostin was independently associated with the components MI (HR = 0.369, 95% CI 0.156–0.871, p = 0.023) and all-cause mortality (HR = 0.297, 95% CI 0.117–0.752, p = 0.010) rather than stroke and repeat revascularization after adjusting for conventional cardiovascular risk factors, CAD severity, angiographic characteristics, and medication. This evidence concerns the gene SOST and Stroke.