CYP27A1 and peripheral arterial disease: In the multivariate linear regression analysis, after adjusting for conventional cardiovascular risk factors, angiographic characteristics, and the use of medication, N-MID osteocalcin(β = − 0.357, p < 0.001), β-CTX (β = 0.200, p = 0.012), PINP(β = 0.207, p = 0.006), CCS class (β = − 0.160, p = 0.017), PAD(β = 0.132, p = 0.042), and multivessel disease(β = − 0.223, p = 0.005) remained significantly associated with serum sclerostin levels (Table 3).