This reinforces the notion that isolated anomalies of FGFR1 are not a diagnostic or grading argument in pediatric glioma, as they have been described in benign glioneuronal (dysembryoplastic neuroepithelial tumors, and Rosette-forming glioneuronal tumor), glial (PA) and malignant neoplasms alike (GBM, and diffuse midline glioma, H3 K27M-mutant) [8, 10]. The gene discussed is FGFR1; the disease is central nervous system cancer.