The depletion and down regulation of SCD1 and ELOVL6 gene expression (indicating low levels of phospholipid MUFAs and high levels of SAFAs) might contribute to the protective mechanisms against diet-induced obesity, hepatic steatosis, and/or type 2 diabetes, as was shown in SCD1 and ELOVL6 knock-out models [45, 46]. This evidence concerns the gene SCD and obesity due to melanocortin 4 receptor deficiency.