Moreover, CIC fusion to non-DUX4 genes such as FOXO4, NUTM1, and NUTM2A seems to lead to histology and features similar to those with CIC-DUX4, although CIC-LEUTX sarcomas are related to CD31 and ETS-related gene expression1,3–6,8. The gene discussed is LEUTX; the disease is sarcoma.