As shown in Table 2, the CK19/GPC3 sub-typing [CK19−/GPC3+: hazard ratio (HR) = 6.413, 95% CI = 0.775–48.693, P = 0.086; CK19+/GPC3+: HR = 49.054, 95% CI = 5.533–434.882, P < 0.001], microscopic vascular invasion (HR = 1.210, 95% CI = 1.393–8.072, P = 0.007), AFP level >261.6 ng/mL (HR = 2.434, 95% CI = 1.060–5.594, P = 0.036) and tumor diameter >3.6 cm (HR = 3.221, 95% CI = 1.973–5.259, P < 0.001) were shown to be independent predictors of RFS. The gene discussed is AFP; the disease is neoplasm.