Recently, multi-dimensional integrated approach with tumor number, size and biomarkers, such as alpha-fetal protein (AFP), epithelial cell adhesion molecule (EpCAM), neural cell adhesion molecule (NCAM), delta-like 1 homolog (DLK1), and cytokeratin 19 (CK19), lens cullinaris agglutin-reactive AFP (AFP-L3) and des-carboxyprothrombin (DCP), et al. showed a great potential as diagnostic and prognostic tool in HCC10,11. The gene discussed is AFP; the disease is neoplasm.