VEGFA and liver dysplastic nodule: Two studies suggest that tubulointerstitial production of VEGF-A has protective role in DN through the maintenance of the peritubular capillary architecture: i) antagonism of VEGF-A signalling in db/db mice induced exacerbation of tubulointerstitial injury, which was related to loss of peritubular capillaries36 and ii) human renal biopsies from diabetic patients exhibited a reduction in tubulointerstitial VEGF-A expression, which was associated to diminished peritubular capillary density9.