IDH1 and neoplasm: When IDH1 was silenced with small-interfering RNA (siRNA) (Supplementary Fig. 10a) in 3D, it led to a disruption in the formation of tumor spheroids (Supplementary Fig. 10b) and suppression of OCR (Supplementary Fig. 10c) together with increased ROS (Supplementary Fig. 10d), compared with no effect in these traits in 2D.