LEF1 and breast carcinoma: IL1β treatment significantly increased Wnt signalling in a 293T cell Wnt-reporter model (p < 0.0001) (Fig. 4a), and Lef1 Wnt target gene expression in breast cancer cell lines (MCF7; p < 0.0001, MDA-MB-231_BH; p = 0.0083) (Fig. 4b).