In a related compound class, the tyrosine phosphatase PTP1b inhibitor ertiprotafib was explored as a novel insulin sensitizer for T2D, based on its ability to improve fasting blood glucose and glucose tolerance in the Zucker diabetic fatty rat45, with triglyceride and free fatty acid lowering effects mediated through inhibition of IκB kinase β46. The gene discussed is INS; the disease is type 2 diabetes mellitus.