Bone marrow AML blasts were cultured ex vivo in the presence of no treatment (NT), Doxo + Cyta or Doxo + Cyta + DAC for 3 consecutive days; and 3 days after drug withdrawal the absolute number of viable CD33 + CD38- CD34 + LSCs was assessed (Fig. 6f). This evidence concerns the gene CD38 and acute myeloid leukemia.