The activation of sterol regulatory element-binding protein-1c (SREBP-1c), a transcriptional activator of lipogenic enzymes such as stearoyl coenzyme-A desaturase1 (SCD1) and fatty acid synthase (FAS), plays an important role in the pathogenesis of NAFLD via an increased rate of fatty acid synthesis5. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.