Whereas CerS6 downregulation in HNSCC cells was observed upon tunicamycin-induced ER stress42, CerS6 upregulation was observed in fatty liver with a concomitant ER stress response during HFD administration, and CerS6 overexpression in Hep3B cells exacerbated ER stress markers under palmitate-induced ER stress. This evidence concerns the gene CERS6 and head and neck squamous cell carcinoma.