GRIK1 and Dravet syndrome: On the other hand, as found in other DS models, basal inhibition was increased in the DG (Supplementary Fig. 8b) and reduced in CA3 pyramidal neurons (Supplementary Fig. 8d), but both alterations were independent of Grik1. In conjunction, these results highlight the association between Grik1-dependent spatial memory impairments and synaptic inhibition but not excitation specifically in the CA1 hippocampal area of Ts2Cje mice.