BRCA1 and ovarian carcinoma: Germline mutations of the breast cancer susceptibility genes 1 and 2 (BRCA1/2) account for the majority of familial breast and ovarian cancers (Antoniou et al., 2003, Ford et al., 1998, King et al., 2003, Metcalfe et al., 2010, Nielsen et al., 2016).