In this way, we detected the induction of transcription factors genes implicated in B-cell differentiation and activation, PAX5 and IRF8 [43–46] as well as of MYBL2, a transcription factor participating in cell cycle progression [47, 48] and recently described as a direct Notch1 target in B cell lymphomas [26]. The gene discussed is IRF8; the disease is B-cell non-Hodgkin lymphoma.