Immunostaining for alpha B-crystallin, alpha-smooth muscle actin, CAM5.2, CD34, chromogranin (Chr), Cytokeratin7, M2A oncofetal antigen (D2–40), Desmin, epithelial membrane antigen (EMA), hemopoietic cell kinase (HCK), neuron specific enolase (NSE), P63, renal cell carcinoma marker (RCC-Ma), S100, Wilms’ tumor 1 (WT1), CD57 and CD15 were negative. This evidence concerns the gene ENO2 and hereditary clear cell renal cell carcinoma.