Immunostaining for alpha B-crystallin, alpha-smooth muscle actin, CAM5.2, CD34, chromogranin (Chr), Cytokeratin7, M2A oncofetal antigen (D2–40), Desmin, epithelial membrane antigen (EMA), hemopoietic cell kinase (HCK), neuron specific enolase (NSE), P63, renal cell carcinoma marker (RCC-Ma), S100, Wilms’ tumor 1 (WT1), CD57 and CD15 were negative. The gene discussed is WT1; the disease is hereditary clear cell renal cell carcinoma.