AKT1 and glioblastoma: Similarly, ZNF207 is a kinetochore component protein, which plays an essential role in spindle assembly and is associated with the progression of glioblastoma multiforme [47], while TBC1D4 has been shown to have its role in GLUT4-cell membrane translocation and has been positively correlated with Akt-pathway in non-small cell lung carcinoma [48].