On the other hand, there was a significant increase in caspase-3 with larger doses of paclitaxel treatment in control group but this effect was not seen in Arr2+ group (Fig. 3b, c), which indicated that larger doses of paclitaxel could be inducing tumor cell apoptosis, but this effect was attenuated by overexpression of Arr2. Here, ARRB2 is linked to neoplasm.