To replicate the results from our genome-wide methylation analysis, we selected the top three hypermethylated CpG islands from the discovery set of 16 GC patients, including A Disintegrin and Metalloproteinase 19 (ADAM19, hg19 chr5:157,002,422-157,002,626), Friend Leukemia Integration 1 (FLI1, hg19 chr11:128,564,720-128,564,959), and Musculin (MSC, hg19 chr8:72,756,005-72,756,149) genes. Here, ADAM19 is linked to gastric cancer.