As shown in Table 1, patients with ADAM19 hypermethylation more often had stage IV GC than those without ADAM19 hypermethylation (P = 0.043); patients with FLI1 hypermethylation had fewer early GC (pT1) than those without FLI1 hypermethylation (P = 0.003). The gene discussed is FLI1; the disease is gastric cancer.