In addition to their usefulness in tumor tissues, some hypermethylated genes identified in plasma have been correlated with clinical significance in hepatocellular carcinoma (HOXA1, EMX1, AK055957, ECE1, PFKP, and CLEC11A), colorectal cancer (AGBL4, FLI1, and TWIST1), and GC (ELMO1, ZNF569, and C13orf18) [6–8]. The gene discussed is FLI1; the disease is neoplasm.