CD8A and nonpapillary renal cell carcinoma: Adopting general features of immune-based groupings described previously (Chen and Mellman, 2017) and incorporating transcriptomic and proteomic features, we defined four tumor subtypes in this ccRCC cohort: (1) CD8+ inflamed, (2) CD8− inflamed, (3) VEGF immune desert, and (4) metabolic immune desert (Figures 6B and S6D; Table S7).