VHL and nonpapillary renal cell carcinoma: The trans-effects of chromosome 3p fully capture the dysregulated VHL/HIF-1 axis that is a hallmark of ccRCC, while the widespread translocation events involving chromosome 3 observed in this study and others (Mitchell et al., 2018; Pavlovich et al., 2003) portray ccRCC as a disorder defined by genomic rearrangements.