Current first-line therapies for advanced ccRCC target VEGF and mTOR (Escudier et al., 2007a, 2007b; Hudes et al., 2007; Motzer et al., 2007, 2008; Sternberg et al., 2010), with ongoing exploration of immune checkpoint inhibitors (Atkins and Tannir, 2018). This evidence concerns the gene MTOR and nonpapillary renal cell carcinoma.