A fibroblast signature that included elevated PDGFRA, extracellular matrix (ECM) and EMT-associated protein abundance, and expression of cancer associated fibroblasts (CAFs) features (POSTN protein and gene FAP mRNA) (t test adjusted p < 0.05) was a unique feature of the CD8− inflamed tumor subtype (Figures 6A, 6B, and S6E; Shiga et al., 2015; Ziani et al., 2018). This evidence concerns the gene POSTN and cancer.