The latter result reflects the aggregation of multiple features in the CD8+ Inflamed subtype that are considered as poor prognosticators in ccRCC, including higher frequency of BAP1 mutations (chi-square test adjusted p < 0.05), increased proportion of higher grade tumors, and increased PD-1/PD-L1 expression (t test adjusted p < 0.05). Here, CD274 is linked to nonpapillary renal cell carcinoma.