The distribution of the immune subtypes across the proteomic groupings contributed to the discriminating gene clusters described in Figure 7B that were also delineated in the immune-based subtyping of ccRCC (Figure 6B), capturing the more dominant molecular signatures of CD8+ inflamed (interferon-γ signaling), CD8− inflamed (platelet degranulation), and VEGF immune desert (hypoxic signaling) tumors, which had a higher prevalence in ccRCC1 (p < 5.0 e–07), ccRCC2 (p < 6.0 e–05), and ccRCC3 (p < 0.0001), respectively. The gene discussed is VEGFA; the disease is nonpapillary renal cell carcinoma.