Moreover, a recent study has shown that pretreatment with Ang-(1–7) significantly reduces leukocyte adhesion and extravasation in diabetic mice in vivo, and also prevented the hyperglycemia-induced increase in adhesion molecules (ICAM-1 and VCAM-1) as well as neutrophil adhesion in vitro [72]. The gene discussed is VCAM1; the disease is Hyperglycemia.