As they are also abnormally regulated in AML samples characterized by NPMc+ mutation [4, 5] we selected: CAspase Recruitment Domain-containing protein 9 (CARD9); Secreted Protein Acidic and Rich Cysteine (SPARC); and Membrane-Spanning 4-domains subfamily A member 3 (MS4A3 or HTm4). This evidence concerns the gene SPARC and acute myeloid leukemia.