TERT and thyroid gland carcinoma: TERT promoter mutations have been associated with poorly differentiated and anaplastic thyroid cancer.16, 17, 18, 19, 21 They are also considered an independent risk factor for persistent disease, distant metastases, and mortality for well differentiated thyroid cancer.16, 20 Given this prognostic information, inclusion of TERT promoter mutation testing in the expanded panel may provide enhanced clinical utility.