Previous studies have demonstrated miR‐590‐3p gets involved in cardiac fibrosis.18, 19, 20 The administration of synthetic miR‐590‐3p lipid formulations immediately after MI in mice results in marked reduction of infarct size and persistent recovery of cardiac function.18 Besides, we previously predicted that zinc finger E‐box binding homeobox 1 (ZEB1) gene, which is a transcription factor and is known for the proliferation and invasion of various cells21, 22 including human cardiomyocytes,10 is the potential target of miR‐590‐3p. The gene discussed is ZEB1; the disease is myocardial infarction.