Because the DAF-7/TGF-β and NPR-1/GPCR pathways are induced by intestinal bloating (Singh and Aballay, 2019a) and act synergistically to elicit pathogen avoidance (Figure 5G, Figure 5—figure supplement 1C), it is likely that animals integrate multiple inputs, including intestinal infection and chemosensation, to induce defense responses. The gene discussed is NPR1; the disease is digestive system infectious disorder.