We defined the clinicopathological characteristics of male, age over 60, Child‐Pugh class in B or C, with hepatitis virus infection, alcohol liver, cirrhosis, serum AFP > 400 μg/L, advanced TNM stage, low tumor differentiation, vascular invasion, and high CTC‐297N7.9 expression as 1 in the score of clinical features; and a score of 0 was designated to the characteristics of female, age ≤60, Child‐Pugh class A, no viral hepatitis, no alcohol liver, no cirrhosis, AFP ≤ 400 μg/L, early TNM stage, and low CTC‐297N7.9 expression. The gene discussed is AFP; the disease is digestive system neoplasm.