For example, Peng et al discovered that TRIM28 could activate autophagy, thus promoting cell proliferation in GBM.67 Regulating autophagy was the key process involved in the chemoresistance and radioresistance of GBM.42 Sensitizing GBM cells to temozolomide via regulating autophagy has been widely reported by scholars.68, 69, 70, 71, 72 With respect to the interplay between autophagy and AS, splicing autophagy‐related genes has been reported to influence autophagy.73, 74 However, no study has reported the correlation between AS and autophagy in GBM. This evidence concerns the gene TRIM28 and glioblastoma.