In the present study, we investigated the risk factors of septic cardiomyopathy and found that: 1) sepsis patients who died in the ICU had significantly higher SOFA scores and more frequent vasopressor use, 2) patients in the septic cardiomyopathy group had significantly higher plasma histone H4 levels, cTnI levels, and more frequent vasopressor use, and 3) elevated plasma histone H4 levels and frequent vasopressor use were important risk factors for septic cardiomyopathy. The gene discussed is TNNI3; the disease is Sepsis.