ITGAM and systemic sclerosis: Genome-wide association studies (GWAS) have now linked several ITGAM single-nucleotide polymorphisms (SNPs) with the risk and severity of disorders such as systemic lupus erythematosus (SLE), systemic sclerosis, and melanoma (Anaya et al. 2012; Hom et al. 2008; Lenci et al. 2012; Nath et al. 2008).