In this study 77His mice were found to be viable and fertile with no obvious spontaneous phenotypes, and no difference in Mac-1 expression was observed on different leukocyte subsets from 77His mice compared to WT. We did not observe any significant effects of the 77His variant on outcomes in two different models of localized inflammation (peritonitis and the dermal Shwartzman reaction), even though previous studies of CD11b null mutant mice have revealed an important contribution of Mac-1 to leukocyte recruitment and the resultant tissue damage (Hirahashi et al. 2006; Jawhara et al. 2017). The gene discussed is ITGAM; the disease is peritonitis.