ITGB2 and Autoimmunity: Likewise, loss or inhibition of Mac-1 has been reported to protect from or exacerbate inflammation and autoimmunity in different murine models, suggesting a complicated immunoregulatory role for this integrin in disease development (Bullard et al. 2005; Kevil et al. 2004; Leon et al. 2006; Soloviev et al. 2011; Stevanin et al. 2017).