ITGAM and systemic lupus erythematosus: GWAS have strongly implicated the SNP rs1143679 in the ITGAM gene, which results in an arginine to histidine change at position 77 in the extracellular domain of CD11b, with the risk of SLE, systemic sclerosis, and certain cancers (Anaya et al. 2012; Hom et al. 2008; Lenci et al. 2012; Nath et al. 2008).