Ours results suggested that the development of vasorenal 1K-1C model of hypertension may cause circadian alterations in CHI and BRS involving diurnal variability in ET1, CGRP and EETs production and support the concept that stable CGRP agonist, EETs analog and especially ET1 antagonist could have preventive and therapeutic potential. The gene discussed is EDN1; the disease is Hypertension.