NEDD4L and neoplasm: To investigate if NEDD4L and HIF-1α could independently predict the GC prognosis, we carried out Cox's univariate regression analysis and found that the parameters including tumor size, metastasis of the lymph node, depth of invasion, differentiation, TNM stage, and the NEDD4L and HIF-1α levels significantly corresponded to OS in GC patients (Table 2).