NEDD4L and gastric cancer: While there was a significant difference between these two groups concerning OS (P < 0.001), no such difference in OS was observed between NEDD4L+/HIF-1α+ and NEDD4L-/HIF-1α- groups (p = 0.07), thus, indicating that a high level of NEDD4L or a low level of HIF-1α may functionally compensate for each other's effects in the prognosis of GC patients.