PLD2 and posterior cortical atrophy: The fact that a combination of EVJ + JWJ is more effective at inhibiting the viability of basal patient-derived PCa cells than when inhibitors are used singly, emphasises that PLD1 and PLD2 must work together in the maintenance of PCa cell viability as is also observed for receptor-mediated endocytosis112 and mTOR activation.113 The effectiveness of these inhibitors is emphasised by our colony formation finding (Supplementary Fig. 2) that even short-term inhibition of PLD2 (and PLD143) has long term effects on PCa cell viability.