PLD2 and breast carcinoma: Interestingly, inhibiting PLD2 in breast cancer cells can block metastasis because PtdOH is unavailable to bind the motor protein KIF5B, which controls membrane trafficking of the MT1-matrix metalloproteinase needed for invadopodia formation and invasion.108 Reduced levels of PtdOH in PCa cells by inhibition of PLD2 could also interfere with migration through integrin activation and the formation of stable adhesions.109