PLD1 and posterior cortical atrophy: We have explained previously43 why our IC50 values for PLD1/2 inhibition of prostate cell proliferation are higher than reported by others.12,50,114 These specific PLD1 and PLD2 inhibitors are based on the antipsychotic agent halopemide, which has been tested in clinical trials and is well tolerated.115,116 Our results in this report show that these PLD1 and PLD2 inhibitors have considerable potential for treating PCa especially if used in combination.