AR and posterior cortical atrophy: In CRPC tissue invading PLD2-positive PCa cells co-stain for chromogranin A (Fig. 2e), an indicator of the development of aggressive androgen-independent neuroendocrine PCa62–64 through Akt/hnRNPK/AR/β-catenin65 and/or N-Myc-driven66 pathways.