PLD1 and posterior cortical atrophy: When cell viability was assessed, the specific PLD2 inhibitor JWJ was much more effective (Fig. 5a) than the dual PLD1/PLD2 inhibitors FIPI or 5WO and even the PLD1 inhibitor EVJ as reported previously.43 At a concentration of 17.5 μM the viability of all PCa cell lines was reduced to almost zero after 48 h treatment.