The overexpression of Hsp60 associates with increased expression of anti-apoptotic proteins Bcl-xl and Bcl-2, and decreased expression of the pro-apoptotic protein, Bax.38 To understand the physiological relevance of our study, we next performed in vivo experiments to determine whether Hsp60 regulates IL-8 production and release in tumour cells in vivo. This evidence concerns the gene BAX and neoplasm.