Deregulated cytokine expression and signalling play a crucial role in developing drug resistance in cancer.39 Aberrant cytokine signalling induces proliferation of tumour cells and facilitates formation of stromal blood vessel networks, which promotes tumour progression and growth.39,40 We report that Hsp60 regulates IL-8 expression and release in colon and prostate cancer. This evidence concerns the gene CXCL8 and Familial prostate cancer.