Thus, we selected two pharmacological inhibitors, Api and TG, which are known to induce autocrine release of IL-8 from cells.29,30 Drug-induced IL-8 signalling promotes resistance to apoptosis in LNCaP and PC-3 prostate cancer cells.31 To determine the importance of IL-8 release on apoptosis, we treated cancer cells with Api and TG alone or in a combination. This evidence concerns the gene CXCL8 and prostate cancer.