CYCS and Familial prostate cancer: Pro-apoptotic protein Bax plays a critical role in the permeabilisation of outer mitochondrial membrane leading to cytochrome c release, caspase activation and apoptosis.37 To address the importance of Bax in IL-8 mediated apoptosis, we used isogenic colon cancer cell lines HCT116 wild type (WT) and Bax−/− as well as isogenic prostate cancer cell line DU145 mock and Bax reconstituted (DU145 Bax+/+) cells.