In addition to IL-8, heat shock proteins (Hsps) or stress proteins have also been associated with TME and poor prognosis in various types of cancer.15 Heat shock protein 60 (Hsp60) expression levels correlates with cervix and colon carcinogenesis.16,17 Hsp60 is a key chaperonin, plays an essential role in the transport and folding of mitochondrial proteins, and is increased in different types of cancer. This evidence concerns the gene HSPD1 and cancer.