Drug-induced IL-8 upregulation has also been reported in dacarbazine treated melanoma cells, etoposide and mitomycin C treated human epithelial carcinoma cells, and doxorubicin treated human small cell lung cancer cells.40 Chemotherapy-induced IL-8 signalling promotes resistance in cancer cells via upregulation of prosurvival protein such as cellular FLICE-inhibitory protein (c-FLIP).31 Abrogation of TG-induced IL-8 expression and increased apoptosis in presence of Api suggests that, the combination of these two drugs may overcome IL-8-mediated cell survival and resistance. This evidence concerns the gene CFLAR and melanoma.