WFS1 and Hyperglycemia: Therefore, a 6-month treatment with liraglutide in this study did not improve glucose tolerance, as expected, and 13-month-old animals were still glucose intolerant (Fig. 1c,d), although a 6-month treatment with the GLP-1 receptor agonist liraglutide delayed the progression of hyperglycemia in Wfs1 KO rats, mostly during the first months of treatment (Fig. 1f).