GLP1R and Hyperglycemia: As expected, 13-month-old KO animals were still glucose intolerant (Fig. 1c,d) (F(1,26) = 103.50, p < 0.001 (genotype)) but, surprisingly, 6-month treatment with the GLP-1 receptor agonist liraglutide delayed the progression of hyperglycemia in Wfs1 KO rats mostly during the first months of treatment (Fig. 1f) (F(1,149) = 27.63, p < 0.001 (genotype); F(1,149) = 3.96, p < 0.05 (treatment)).