Secondly, the hot spot mutations of POLE gene in Chinese lung cancer were c.857 C > G (p.P286R) and c.2091dupC (p.F699Vfs*11), while the hot spot mutation recorded by COSMIC were c.857 C > G (p.P286R) and c.1231 G > C/T (p.V411L). The gene discussed is POLE; the disease is lung cancer.