Upon ligand binding, Notch1 is cleaved by γ-secretase, releasing the intracellular domain (NICD), which translocates into the nucleus and forms a complex with the CSL DNA-binding protein to activate HSF1; HSF1, in turn, promotes Snail activation and regulates the TRX1/TXNIP and TRX1/ASK1 complexes, leading to reduced NLRP3 inflammasome activation and ROS-induced hepatocellular apoptosis/necrosis during IR-triggered liver inflammation. This evidence concerns the gene NOTCH1 and Hepatitis.