MAPT and Alzheimer disease: The identification of the aforementioned epitopes in the sarkosyl-insoluble proteome of APPswe/PS1dE9 mice indicates that murine tau undergoes the complete sequence of phosphorylation events that have been associated with the development of cytoskeletal pathology in AD, substantiating the detection of Gallyas- and thioflavin-S-positive lesions in aged transgenic animals48.