Genetically-inherited and sporadic forms of Alzheimer’s disease (AD) are characterized by a common set of hallmark brain lesions, which include the aggregation of amyloid-β (Aβ) peptide into fibrillar plaques, neuroinflammation, aggregation of hyperphosphorylated MAPT (tau) protein into neurofibrillary tangles (NFTs), and neurodegeneration. Here, MAPT is linked to Alzheimer disease.