PXK and systemic sclerosis: PXK-rs4076852 is in high linkage disequilibrium (LD) with PXK-rs2176082 (r2 = 0.92), which was reported to be associated with SSc in Martin et al.13 However, two Immunochip studies conducted by Mayes et al.9 and Zochling et al.12 showed that the primary association in this genomic region was with the nonsynonymous SNP DNASE1L3-rs35677470 (R206C), not present in our SNP panel.