There were significant enrichments of associations with SSc within H3K27ac, H3K4me1, H3K4me2, and H3K9ac marks—among others—of several CD4+ T cells (T helper, T regulatory, etc), CD8+ T cells, primary B cells, monocytes, primary neutrophils, and thymus (Fig. 3, Supplementary Data 8). Here, CD8A is linked to systemic sclerosis.