SSc-associated variants displayed the most significant enrichments in H2BK15ac and H2BK20ac marks in the GM12878 lymphoblastoid cell line (OR = 37.33, enrichment p value (Penr) = 4.84 × 10−14; OR = 12.79, Penr = 2.40 × 10−10, respectively), followed by H3K79me1 in primary Natural Killer (NK) cells (BLD.CD56.PC) (OR = 12.23, Penr = 5.73 × 10−09) and primary T cells (BLD.CD3.PPC) (OR = 12.58, Penr = 9.78 × 10−09). The gene discussed is NCAM1; the disease is systemic sclerosis.