The third novel finding is that CXCR7 selectively regulates NMDAR-mediated synaptic transmission of hippocampal dentate GCs in the epilepsy model by modulating the cell membrane expression of NR2A and NR2A-mediated synaptic transmission, changes that are almost completely eliminated by blocking ERK1/2 signaling. This evidence concerns the gene ACKR3 and epilepsy.