However, our data showing the control of osteoblast differentiation by SIK1, the study on SIK2 function for PTH responses in osteocytes37, and the demonstration of SIK2/3 involvement in osteoclastogenesis64 all indicate that SIK inhibition is beneficial for conditions requiring bone mass increases, such as osteoporosis. The gene discussed is SIK2; the disease is osteoporosis.