SIRT1 and alcoholic liver diseases: Consistent with our results, a recent report showed that Sirt1 protein expression could be induced by treatment of A549 cells with a water extract of KRG at 500 μg/mL [55]; moreover, feeding with KRG at 250 and 500 mg/kg for 4 weeks increased the expression of Sirt1 in alcoholic liver disease model mice [56].