Interestingly, a circRNA (circRNA ID in circbase: hsa_circ_0017252, http://www.circbase.org/), which was derived from the AKT3 gene locus (Fig. 1c), was significantly decreased in the ccRCC tissues compared with normal kidney tissues, and this result was consistent with the circRNA microarray result (Fig. 1d and e). The gene discussed is AKT3; the disease is nonpapillary renal cell carcinoma.