microRNA 223-3p is another widely documented microRNA which has been reported to regulate cardiac fibrosis after myocardial infarction by targeting RAS p21 protein activator 1 (RASA1) [9], and regulated expression of voltage-gated K+ channel Kv4.2 in acute myocardial infarction [10]. This evidence concerns the gene RASA1 and acute myocardial infarction.