Firstly, the population was a contemporary European multicentric group of patients with stable angina, receiving optimal medical treatment and with a lower prevalence of obstructive CAD (35% of patients with CTA stenosis > 50% and 11% with stenosis > 70%) than usually found either in patients with acute coronary syndromes [7, 8] or referred to coronary catheterization in whom circulating PCSK9 had been previously measured [9, 10]. The gene discussed is PCSK9; the disease is acute coronary syndrome.