Additionally, MM cells express various Wnt family members including Wnt2b, Wnt3, Wnt4 and Wnt5a [13,14,33]; blocking of Wnt3a activity by secreted frizzled related peptide 4 (SFRP4) inhibits cell proliferation and migration of JU77 and ONE58 MM cells [43]. This evidence concerns the gene WNT5A and Miyoshi myopathy.