FLT3 and acute myeloid leukemia: Other studies revealed that C-18 ceramide [64] and the mitochondria-targeted ceramide analog LCL-461 [65] induced lethal mitophagy in head and neck squamous cell carcinoma and FLT3-ITD (Fms-like tyrosine kinase 3-internal tandem repeat)-positive acute myeloid leukemia (AML) cells, respectively.